Researcher Dr. uttam Pati

Former Chairman & Dean School of Biotechnology, Jawaharlal Nehru University, New Delhi

2017 - Emeritus Medical Scientist, Indian Council of Medical Research, 2015 - 2017, Dean, School of Biotechnology, Jawaharlal Nehru University, 2006-2007, Founder Dean, School of Biotechnology; 2005-2006, Chairman, Centre for Biotechnology; 2002- Professor; 1999 – 2001, Chairman, Centre for Biotechnology, Jawaharlal Nehru University; 1998, Acting Director, Genetic Engineering Unit, Jawaharlal Nehru University; 1994-2002, Associate Professor, Centre for Biotechnology Jawaharlal Nehru University; 1991-1994, Assistant Professor of Medicine, Molecular Biology & Pharmacology, School of Medicine, Augusta, Georgia, USA; 1985-1990, Associate Research Scientist, Yale University School of Medicine, CT, USA; 1983-1984, Research Associate, Yale University, CT, USA; 1982-1983; Research Associate, Massachusetts Inst. of Technology, Cambridge, USA; 1981-1982, Post- doctoral Research Fellow, Max-Planck Inst, Germany; 1976-1978, Lecturer in Chemistry, Regional College of Education, Bhubaneswar.

Services

What I Do?

My Work

what i’ve done?

HONORS AND AWARDS

International Publications Books

Books and Chapters:
U Pati, 2022, Mind Phenomenon
U Pati, Gene Therapy: Concept to Applications. The Gene & its Engineering, Edited by H K Das, Wiley India
U Pati 2005, Population genetics as a tool for health and sustainable environment. Population and sustainable development in India, Author press, New Delhi, edited by E Haq

  • A Tomar & U Pati, Mitochondrial Import protein CHCHD4 prevents p53 aggregation via Stabilization of p53 wild and mutant phenotype in hypoxia, FEBS Jour (in review)
  • A Tomar, P Basnett, P Uysal-Onganer, U Pati, I Roy, 3D Disease Modelling of hard and soft cancer using PHA based scaffolds, Cancers, 2022,14 (14), 3549
  • S Taxak & U Pati, Oxygen-responsive p53 tetramer-1 octamer switch controls cell fate, bioRxiv,2019, https://doi.org/10.1101,841668
  • S Taxak & U Pati, Oxygen-generated spatial distribution of cell population links to p53 status, bioRxiv, 2019. 12.27.889394;doi:https//doi.org/10.1101/2019.12.27.889394
  • Deepa, Mittal A, Taxak S, Tandon V, U Pati, Oxygen-releasing manganese clay hybrid complex triggers p53-mediated cancer cell death in hypoxia. Biochem. Pharmacol,2020,178,11405
  • E Madan et al. HIF-transcribed p53 chaperones HIF1a, Nucleic Acids Res. 2019 Sep 20. pii: gkz766. doi: 10.1093/nar/gkz766. [Epub ahead of print] PMID:31538203
  • K Tanwar & U Pati. Inhibition of apoptosis via CHIP-mediated proteasomal degradation of TAp73α, J Cell Biochem. 2019;120:11091-11103
  • M Maan & U Pati. CHIP promotes autophagy-mediated degradation of aggregating mutant p53 in hypoxic conditions P53-CHIP chaperone synergy supports CHIP-mediated lysosomal degradation of aggregating p53 mutants, FEBS Jour. 285, 17, (3197-3214), (2018)
  • N Chanana and U Pati ORP150-CHIP chaperone antagonism control BACE1-mediated amyloid processing, , J Cell Biochem, 2018 Jun;119(6):4615-4626
  • M Hossein and U Pati, Biochemical Characterization of Recombinant Baculovirus 373 K/E p53 Protein, Int Jour of Contemporary Research and Review March, 2018, 09,Issue 03,20204-20223
  • A Singh & U Pati CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of -secretase, Aging Cell (2015), 1-10, Doi: 10.1111/acel.12335
  • R Gogna, E Madan, M Khan, U Pati, P Kuppusamy. p53’s choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53Lys162acetylation. EMBO Jour (2013)5, 1-22
  • M Azam, S I. Al-Resayesa, A Trzesowska-Kruszynskab, R Kruszynsk, A Verma, U Pati. Apoptosis induction by chiral anionic binuclear Zn(II) complexes based on (1S,2S)-(+)-Cyclohexanediamine in HCT cells with different p53 status. Inorganic Chemistry (2014)46
  • E Madan, R Gogna, B Keppler, U Pati, p53 Increases Intra-cellular calcium release by transcriptional regulation of calcium channel TRPC6 in GaQ3-treated cancer cells, PloS One (2013) 8 Issue 8 | e71016
  • R Gogna, P Kuppusamy, M Bhatt, A Ali Mahdi, U Pati. SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of ASK-1-TRX Complex 2012 Mol Cell Biol (2013) 33, No 7, 1285-1302
  • E Madan, R Gogna , U Pati. p53Ser15 Phosphorylation disrupts p53-RPA70 complex and induces RPA70- mediated DNA repair in hypoxia, Biochem Jour (2012) 443 (3) 811-820
  • R Gogna, E Madan, P Kuppusamy, U Pati. Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild type conformation and post-translational modifications, Cell Death & Disease, Cell Death and Disease (2012) 3, eK; doi:10.1038/cddis.2012.15
  • R Gogna, E Madan, P Kuppusamy, U Pati. Chaperoning of Mt p53 by Wt p53 causes hypoxic tumor regression. Jour Biol Chem, (2012) 287, No.4, 2907-2914, 2012 Published on December 6, 2011 as Manuscript M111.317354
  • E Madan, R Gogna , P Kuppusamy , M Bhatt , U Pati , A Ali Mahdi, TIGAR Induces p53-Mediated Cell-Cycle Arrest by Regulation of RB-E2F1 Complex. British Jour Cancer (2012), 1–12
  • E Madan, R Gogna, M Bhatt, U Pati, P Kuppusamy, A Ali Mahdi. Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor. Oncotarget (2012) 2, No 12, 948-957
  • R Gogna, E Madan, P Kuppusamy, U Pati. P53 core domain modifications determine apoptotic and necrotic death in cancer cells. Antioxidant & Redox Signaling, (2012) 16, 400-412
  • R Gogna, E Madan, B Keppler, U Pati. Gallium compound GaQ3-induced Ca2+ signaling triggers p53-dependent and independent apoptosis in cancer cells, British Jour Pharmacology (2012) 166 617–636; 2011
  • M Shrivastava, S. Vivekanandhan, U Pati, M Behari, and T K. Das. Mitochondrial Perturbance and Execution of Apoptosis in Platelet Mitochondria of Patients with Amyotrophic Lateral Sclerosis. International Journal of Neuroscience, 121, 149–158, 2011
  • M Shrivastava, T K. Das, M Behari, U Pati, Vivekanandhan. Ultrastructural Variations in Platelets and Platelet Mitochondria: A Novel Feature in Amyotrophic Lateral Sclerosis. Ultrastruct Pathol, 35(2), 52–59, 2011
  • A Sharma, A Ali, R Gogna, A Singh, U pati. The role of p53 amino terminus domain in displaying chaperone like function. PloS One 4 (10), 2009, 7159-
  • S. Subhankar ,U Pati, S. Chandna, U. Stress response of a p53 homologue in the Radioresistant Sf9 insect cells, Int Jour Rad Biol 85 (3), 2009, 238-249
  • SK Dubey, A K Sharma, U Narain, K Mishra, U Pati. Design, synthesis, and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine, and demethylenated piperic acid and study of their antimicrobial and anti-proliferative properties. Eur j Med Chem. 43,2008, 837-449
  • V tripathi, A Ali, R Bhat, U Pati. CHIP chaperones wild type p53 tumor suppressor protein. Jour Biol Chem, 282, 39, 2007, 28441-454
  • N Kapoor, A K Sharma, V Dwivedi, A Kumar, U Pati, K Mishra. Telomerase-targeted anti cancer bioactive prodrug by antisense-based approach. Cancer Lett. 248, 2007, 245-250
  • R.Chauhan, R. Handa, Trinath P. Das, and U. Pati. Over expression of TATA-binding protein (TBP) and p53 and autoantibodies to these antigens are features of systemic sclerosis, systemic lupus erythematosus, overlap syndromes. Clin Exp Immunol136, 2004, 574-584
  • S. Negi, S. Singh, N. Pati, V. Handa, R. Chauhan, and U. Pati. A proximal tissue-specific and a distal negative regulatory module control apo(a) gene transcription. Biochem Jour 378, 2004, 1-9
  • V. Handa, Mahboob-ul-Hussain, N. Pati, and U. Pati. Multiple liver-specific factors bind to a 64 bp element and activate apo(a) gene. Biphy. Biochem. Res. Comm. 292, 2002, 243-249
  • U. Pati. Atherosclerosis and the genetic switch. Biotechnology in Health Care. Eds. T. Lazzar Mathew. Delhi, 2001
  • U Pati and N Pati Lipoprotein(a), Atherosclerosis, and Apolipoprotein(a) Gene Polymorphism. Mol Genet Met 71, 2000, 87 – 92
  • U Pati and J.K.Gambhir. Apolipoprotein(a) Polymorphism and Plasma Lipoprotein(a) levels. Indian Heart Journal 52, 2000, 171-172
  • N. Pati, A. Rouf and U. Pati. Simultaneous mutations (A/G-418 and C/T-384) in the apo(a) promoter of individuals with low LP(a) levels, Mol. Genet. Met. 69 ,2000, 165–67.
  • N. Pati and U. Pati. Paraoxanase gene polymorphism and coronary artery disease in Indian subjects, Int. Jour. Cardiol. 66, 1998, 165-168.
  • U.K. Pati. Human RNA polymerase II subunit hRPB14 is homologous to yeast RNA polymerase I, II and III subunit (AC19 and RPB11) and is similar to a portion of the bacterial RNA pol II subunit. Gene 145, 1994, 289-292.
  • M. Hirakata, Y. Okano, U. Pati, A. Suwa, J. Hardin and J. Craft Identification of autoantibodies to RNA polII: Occurance in systemic sclerosis and association with autoantibodies to RNA polI, III. J. Clin. Invest. 91, 1993, 2665-2672.
  • U.K. Pati. Novel vectors for expression of cDNA encoding the epitope-tagged proteins in mammalian cells. Gene 114, 1992, 285-288.
  • M. Hirakata, J. Kanungo, U.K. Pati, A. Suwa, Y. Okano, and J.A. Hardin. The auto-antigenic domain of RNA polymerase II resides at the carboxyl terminal. Arthritis Rheum. 35 (9), 1992, S62-S62.
  • L. Denner, J. Hongjun, R.D. Owen, G.L. Kato, C.L. Clarke, and U.K. Pati. Steroid receptors, transcription factors, and gene expression Cancer. Res. 50, 1990, 6430-6436.
  • U.K. Pati and S. Weissman. The amino acid sequence of human RNA polII subunit hRPB33 is highly conserved in eukaryotes J. Biol. Chem. 265, 1990, 8400-8403
  • U.K. Pati and K. Wiesner. Synthesis of 17b- (3’-thiphenyl) 15b-androstane-3b, 14-b-diol 3-bD glucopyranoside, an-antitropic cardiac glucoside. Steroids 55, 1990, 65-68.
  • U.K. Pati and S.M. Weissman. Converted domains of mammalial RNA polymerase II. Cold Spring Harbor Journal of Cancer Cells 65, 1989, 157.
  • U.K. Pati and S. Weissman. Isolation and molecular characterization of cDNA encoding the 23 K subunit of human RNA polymerase II complex. J. Biol. Chem. 264, 1989, 13114-13121.
  • U.K. Pati and K. Wiesner Synthesis of 5b-androstane-17b-(oxocyclohex-2’-en-3’-yl)-3b, 14b-diol 3b-D-glucopyranosdie, a potent cardiac glucoside with high safety margin. Heterocycles 29, 1989, 1275-1282.
  • U.K.Pati and S.M. Weissmn. Molecular characterization of mammalian RNA polymerase II complex. Cold Spring Harbor Journal of Cancer Cells. 64, 1988, 121- 24.
  • K. Stone, U. Pati, S. Weissman, S. Sebti, J. Lazo and K. Williams. Isolation and re-purification of picomole amounts of peptides on microbore HPLC columns ASBMB Journal of Protein Purification, 37, 1987, 180-81.
  • F. E. Ziegler, S. I. Klein, U.K. Pati, and T.F. Wang. Acylic Diastereoselection as a synthetic route to quassinoids : A claisen F.E. Ziegler, U.K. Pati, S.C rearrangment based strategy for bruceantin. Jour. Am. Chem. Soc. 107, No. 9, 1985, 2730-2737.
  • F. E. Ziegler, K. J. Hwang, J. F. Kadow, S. I. Klein, U. K. Pati, T. F. Wang. Practical Routes to 2 functionalized decalones for the synthesis of quassinoids. Jour. Org. Chem. 51(24), 1986, 4573-457
  • U Pati 2012, Management of plagiarism and misconduct in USA Ivy league schools. SSV News 10 (1)28-33
  • U Pati, How do cells communicate. Philosophical & scientific models of understanding consciousness, Nava Nalanda Mahavihara, 9th Nalanda Dialogue Edition, 2013
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